The Dietz Lab at Technische Universität München


Designing the sequences of biomolecules to construct molecular devices and machines.

Inspired by the rich functionalities of natural macromolecular assemblies such as enzymes, molecular motors, and viruses, we investigate how to build increasingly complex molecular structures. Our goal is to build molecular devices and machines that can execute user-defined tasks. Molecular self-assembly with DNA is an attractive route toward achieving this goal. DNA origami in particular enables building nanodevices that can already be employed for making new discoveries in biomolecular physics and protein science.

 

In the long term we hope to contribute to the creation of molecular machines and systems that have practical benefits for everyday life. This includes potential uses in medicine – for diagnosis and therapy – and synthetic enzymes for biologically inspired chemistry. 

An 18 min summary of our vision and current activities. See also here: Molecular machines of the future. Thanks to the TEDx TUM team.



Recent publications from this laboratory:

 

K. Wagenbauer, C. Sigl, and H. Dietz: "Gigadalton-scale shape-programmable DNA assemblies", NATURE 2017

F. Praetorius, B. Kick, K. Behler, M. Honemann, D. Weuster-Botz, and H. Dietz: "Biotechnological mass production of DNA origami", NATURE 2017

F. Praetorius and H. Dietz: "Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes", SCIENCE 2017

F. Kilchherr, C. Wachauf, B. Pelz, M. Rief, M. Zacharias, H. Dietz: "Single-molecule dissection of stacking forces in DNA", SCIENCE 2016

T. Gerling, K. Wagenbauer, A. Neuner, H. Dietz: "Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components", SCIENCE 2015


We are thankful for financial support from the Deutsche Forschungsgemeinschaft via the Excellence Clusters CIPSM and NIM, through the SFB863, and via the Gottfried-Wilhelm-Leibniz Prize program. Further support comes from the European Research Council.